A team co-led by Lawrence Kwong, Ph.D., assistant professor of Translational Molecular Pathology, conducted an integrative genomic analysis of patient samples through The Cancer Genome Atlas, identifying two potential targets for treating tumors with mutations in IDH1 or IDH2 genes. (2)Department of Gastroenterology, Hepatology and Nutrition, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA. by Ignacio Wistuba, M.D., chair of Translational Molecular Pathology, says Milind Javle, M.D., professor of Gastrointestinal Medical Oncology. Clinical trial ABBV-399. KW - BRCA-associated. Read more about the symptoms, diagnosis, and treatment of … Cholangiocarcinoma (Bile Duct Cancer) Clinical Trials Cholangiocarcinoma clinical trials focus on newly discovered treatments, allowing participants to start benefiting from those treatments as quickly as possible while researchers compare their effectiveness to the current standard of care. participate in clinical trials for CCA; Please note this map incorporates clinical and scientific activity for providers across the nation to find the most active healthcare providers and researchers in CCA. Median survival of patients newly diagnosed with the disease is less than a year. In a phase 2 clinical trial, the oral, FGFR1-3 selective tyrosine kinase inhibitor (TKI), infigratinib correlated with promising anticancer activity in addition to manageable safety as treatment of patients with chemotherapy-refractory cholangiocarcinoma whose tumors harbor FGFR2 fusions, according to results presented during the American Association of Clinical Oncology (ASCO) 2021 … Get details about our clinical trials that are currently enrolling patients. As part of our mission to eliminate cancer, MD Anderson researchers conduct hundreds of clinical trials to test new treatments for both common and rare cancers. ABC294640 also inhibits proliferation and induces apoptosis of cholangiocarcinoma cell lines. 7 7 University of Southern California Kenneth Norris Cancer Center, Los Angeles, CA. marions. A $500,000 gift from the Janet M. and George J. Ehni III estate and an initial gift of $100,000 by the Linda A. Blum Fund for Cholangiocarcinoma Research will fund major infrastructure investment to better study the disease, including an integrated molecular and pathology biorepository that will include frozen tumor samples, blood and tissue arrays and clinical information associated with the samples. Clinical Trials Video Transcript . Cholangiocarcinoma — cancer of the bile ducts — is treated with chemotherapy and surgery. Therefore, locoregional liver-directed therapies can provide an opportunity to control intrahepatic disease with minimal systemic side effects. Bile duct cancer survivors often have to deal with side effects. They need to be studied. “This will provide new capacity to perform additional experiments, improve profiling of tumors and develop new cholangiocarcinoma cell lines,” Kwong says. Started by: marions. Bringing the most exciting new agents for cancer treatment more quickly from the laboratory to clinical trials is the goal of MD Anderson’s Phase I Clinical Trials Program in the Department of Investigational Cancer Therapeutics. Learn about our graduate medical education residency and fellowship opportunities. information page may be the best place to start. Conclusion. Such translational research, taking information from human tumors back to lab experiments where researchers will gain the understanding necessary to develop new treatments for testing in clinical trials, is a vital aspect of a new, multidisciplinary effort targeting cholangiocarcinoma at MD Anderson. marions. Clinical trials … Baptist MD Anderson Clinical Trials 904.202.7468 poonam.neki@bmcjax.com. Our Gastrointestinal Center, Houston, Texas, MD Anderson cancer Center 9 9 the University of California San... 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