Ivermectin, an unconventional agonist of the glycine receptor chloride channel. High-resolution structures of multiple 5-HT. Mechanisms of activation and desensitization of full-length glycine receptor in lipid nanodiscs. doi: 10.7554/eLife.57870. The unusual quakes were described as "more than 600 quakes over the past 10 days in a basin 150 miles [240 km] southwest of Newport". Many of our member libraries are currently adjusting their services to the public. The 1700 Cascadia earthquake occurred along the Cascadia subduction zone on January 26, 1700 with an estimated moment magnitude of 8.7–9.2. Epub 2016 Jul 11. are 0.9, 0.9 and 0.7 A, respectively, suggesting that the movement of the TMD is rigid-body-like. Densities are sharpened…, Extended Data Figure 6. The rings of the dead trees indicate that they died around 1700, and it is believed that they were killed when the earthquake occurred and sank the ground beneath them causing the trees to be flooded by saltwater. Le Monde de Narnia, chapitre 3 : L'Odyssée du Passeur d'Aurore 2010. The Oregon is a ship that was originally introduced in the Dirk Pitt novel Flood Tide. Residues that likely interact with disease-causing residues are labeled in italics. The books follow the mysterious "Corporation" and … 2 Department of Biochemistry and Biophysics, University of California San Francisco, 600 16th Street, San Francisco, California 94158, USA. Juan Cabrillo runs the ship like a business, and the crew helps the CIA to thwart terrorist activities. Structure and Pharmacologic Modulation of Inhibitory Glycine Receptors. Comparison of GlyR with other Cys-loop receptors, Extended Data Figure 8. 2001 Apr 20;276(16):12556-64. doi: 10.1074/jbc.M011264200. Find local businesses, view maps and get driving directions in Google Maps. 12 Items that share the Concept Cabrillo, Juan (Fictitious character) -- Fiction Corsair : a novel of the Oregon files, Clive Cussler with Jack du Brul Borrow it Plan, Detail Garden St. Gall, c.800 AD. Comparison of ivermectin…, Extended Data Figure 6. We've developed a suite of premium Outlook features for people with advanced email and calendar needs. Juan . A System for Assessing Dual Action Modulators of Glycine Transporters and Glycine Receptors. [9][10], A small tectonic plate in the eastern North Pacific, This article is about the entire Juan de Fuca Plate, or more specifically the middle fragment. 8,583,104 Injection of CO2 would lead to the formation of stable carbonates. The 'Big One' will hit when Juan de Fuca, a 700-mile chunk of the Pacific Ocean, slides under Canada and America, causing the entire coastal region to sink at least six feet. [3] Evidence of this earthquake is also seen in the ghost forest along the bank of the Copalis River in Washington. Check your home library website or social media sites for details about current services and offerings. Strychnine and ivermectin bind at subunit interfaces, Figure 4. The Juan de Fuca Plate is bounded on the south by the Blanco Fracture Zone (running northwest off the coast of Oregon), on the north by the Nootka Fault (running southwest off Nootka Island, near Vancouver Island, British Columbia) and along the west by the Pacific Plate (which covers most of the Pacific Ocean and is the largest of Earth's tectonic plates). The second novel of the Oregon Files series written by the author Jack Du Brul was published in the year 2006 by the Berkley Books publishing house. The trail is busy from mid-June through to early September, with peak times in July and August. The novel was titled ‘Skeleton Coast’. Sheipouri D, Gallagher CI, Shimmon S, Rawling T, Vandenberg RJ. CX. Representative densities of the three reconstructions of GlyR. For the northern fragment, see, Hawley William B. and Allen, Richard M. (July 3, 2019), "Sizes of Tectonic or Lithospheric Plates", "Seaside, Oregon, Tsunami Pilot Study GIS, USGS Data Series 236, home page", "The Earthquake That Will Devastate the Pacific Northwest", "Fault slip and seismic moment of the 1700 Cascadia earthquake inferred from Japanese tsunami descriptions", "Unusual Earthquake Swarm Off Oregon Coast Puzzles Scientists", "Carbon dioxide sequestration in deep-sea basalt", "Sub-seafloor Carbon Dioxide Storage Potential on the Juan de Fuca Plate, Western North America", "The Fragmented Death of the Farallon Plate", "A Tectonic Plate Under Oregon Is Being Slowly Ripped Apart", National Geographic on Japanese records verifying an American earthquake, https://en.wikipedia.org/w/index.php?title=Juan_de_Fuca_Plate&oldid=1000293084, Short description is different from Wikidata, Wikipedia articles with WorldCat-VIAF identifiers, Creative Commons Attribution-ShareAlike License, This page was last edited on 14 January 2021, at 14:46. The Juan de Fuca Plate is a small tectonic plate (microplate) generated from the Juan de Fuca Ridge that is subducting under the northerly portion of the western side of the North American Plate at the Cascadia subduction zone. Reddit. Huang X, Chen H, Michelsen K, Schneider S, Shaffer PL. San Giminiano, Italy K. Helphand- 09/73. Strychnine and ivermectin bind at…, Figure 3. Epub 2015 Sep 28. These structures illuminate the GlyR mechanism and define a rubric to interpret structures of Cys-loop receptors. Strychnine binding site (+; light blue) (−; gray); view is parallel to the membrane (. It all started, when Juan Cabrillo and his crew mated had received orders to rescue a Pakistani boy from the terrorists. Please enable it to take advantage of the complete set of features! Superimposition of TMD…, Extended Data Figure 8. This oceanic crust has primarily been subducted under the North American Plate, and the Eurasian Plate. Superimposition of TMD between str- and gly-GlyR (a), str- and gly/ivm-GlyR…, Extended Data Figure 9. Representative densities of…, Extended Data Figure 4. See this image and copyright information in PMC. Tweet. Relative to the glycine-bound state, strychnine expands the agonist-binding pocket via outward movement of the C loop, promotes rearrangement of the extracellular and transmembrane domain 'wrist' interface, and leads to rotation of the transmembrane domain towards the pore axis, occluding the ion conduction pathway. Research Interests The Jungle is book eight in The Oregon Files by Clive Cussler. Crystal structure of human glycine receptor-α3 bound to antagonist strychnine. The (+)subunits are shown in darker colors. The image was designed by Thomas Wimberly for “Global Forefront,” an open call for messages that promote health and public safety in the time of Covid-19. Nature. The Juan de Fuca Plate itself has since fractured into three pieces, and the name is applied to the entire plate in some references, but in others only to the central portion. This map was created by a user. Biomolecules. Would you like email updates of new search results? The M2-M3 loop, residues Ser289-Ala298, is excluded from the comparison. Thermophoretic analysis of ligand-specific conformational states of the inhibitory glycine receptor embedded in copolymer nanodiscs. Here we report electron cryo-microscopy structures of the zebrafish α1 GlyR with strychnine, glycine, or glycine and ivermectin (glycine/ivermectin). Email. COVID-19 is an emerging, rapidly evolving situation. Plan St. Gall, c.800 AD. NIH Find helpful customer reviews and review ratings for The Jungle: Oregon Files #8 (The Oregon Files) by Clive Cussler (1-Mar-2012) Paperback at Amazon.com. The plot of the continues to feature the same characters as in the first novel of the series. This subducting plate system has formed the Cascade Range, the Cascade Volcanic Arc, and the Pacific Ranges, along the west coast of North America from southern British Columbia to northern California. Overall conformational changes of the…, Figure 6. Arcade San Juan Capistrano, California K. Helphand- 10/90. The r.m.s.d.  |  This site needs JavaScript to work properly. It is estimated that 100 years of US carbon emissions (at current rate) could be stored securely, without risk of leakage back into the atmosphere. Campsites are first come, first served with the exception of China Beach Campground – which isn’t really on the trail anyway. The subterranean quakes were detected on hydrophones, and scientists described the sounds as similar to thunder, and unlike anything previously recorded. Juan Cabrillo is a fictional character in the Oregon Files series of adventure novels by Clive Cussler.The series revolves around the Oregon, a state-of-the-art maritime vessel disguised as a rusting heap of junk.Cabrillo is the main character of the series as chairman … Corsario (Juan Cabrillo 6) Clive Cussler Author Jack du Brul Author (2014) The Silent Sea Oregon Files (Series) Book 7 Clive Cussler Author Jack du Brul Author (2010) Mirage Oregon Files (Series) Book 9 … [4] Japanese records indicate that a tsunami occurred in Japan on 26 January 1700, which was likely caused by this earthquake. (Page 2) Strychnine arrests the receptor in an antagonist-bound closed ion channel state, glycine stabilizes the receptor in an agonist-bound open channel state, and the glycine/ivermectin complex adopts a potentially desensitized or partially open state. Cloister France K. Helphand- 07/83. They are a consortium of Japanese shipping magnates, and their fortunes are being threatened by … Find Juan Braun's phone number, address, and email on Spokeo, the leading online directory for contact information. We have a separate entry for the Oregon Files which covers all of the authors. St-Martin du Canigou Pyrennes, France K. Helphand- 09/94. 2021 Jan;73(1):310-520. doi: 10.1124/pr.118.015552. Expand your Outlook. The strychnine-sensitive glycine receptor (GlyR) mediates inhibitory synaptic transmission in the spinal cord and brainstem and is linked to neurological disorders, including autism and hyperekplexia. The Juan de Fuca Trail is open year round and reservations are not required for backcountry camping. [7][8], In 2019, scientists from the University of California, Berkeley published a study in Geophysical Research Letters in which they reported that by utilizing data from over 30,000 seismic waves and 217 earthquakes to create a three-dimensional map, they had revealed the existence of a hole in the subducted part of the Juan de Fuca Plate, and speculated that the hole is an indication of a 150 kilometres (93 mi) deep tear in the plate along a "preexisting zone of weakness." Open Library is an initiative of the Internet Archive, a 501(c)(3) non-profit, building a digital library of Internet sites and other cultural artifacts in digital form.Other projects include the Wayback Machine, archive.org and archive-it.org Epub 2020 Aug 25. The deformation may cause the plate to fragment, with the remaining un-subducted small pieces becoming attached to other plates nearby. USA.gov. Such differences on side chains weaken or strengthen the interaction of ivermectin with M3 or M1 in GlyR, respectively, in comparison to that in GluCl. Mark L. Mayer: collaborator: 1990-2000: NIH (Sabbatical) BETA: Related publications Publications. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. The quakes were unlike most quakes in that they did not follow the pattern of a large quake, followed by smaller aftershocks; rather, they were simply a continual deluge of small quakes. Juan Du New research indicates that an increase in minimum wages can have important health benefits—a finding that is relevant to public debates about both … Trump sent Feds to Portland, but will coddle White Supremacist militias who invaded Oregon State House. Positions of residues…, Extended Data Figure 9. J Biol Chem. 2020 Sep 23;120(18):10298-10335. doi: 10.1021/acs.chemrev.9b00830. You can help our author matching system! Epub 2012 Oct 4. Kumar A, Basak S, Rao S, Gicheru Y, Mayer ML, Sansom MSP, Chakrapani S. Nat Commun. Most differences are located in the termini of transmembrane helices, which are either close to the M2-M3 loop, or close to the intracellular gate −2′Pro. 2015 Oct 8;526(7572):277-80. doi: 10.1038/nature14972. 2020 Oct 16;9:e57870. Barnes NM, Ahern GP, Becamel C, Bockaert J, Camilleri M, Chaumont-Dubel S, Claeysen S, Cunningham KA, Fone KC, Gershon M, Di Giovanni G, Goodfellow NM, Halberstadt AL, Hartley RM, Hassaine G, Herrick-Davis K, Hovius R, Lacivita E, Lambe EK, Leopoldo M, Levy FO, Lummis SCR, Marin P, Maroteaux L, McCreary AC, Nelson DL, Neumaier JF, Newman-Tancredi A, Nury H, Roberts A, Roth BL, Roumier A, Sanger GJ, Teitler M, Sharp T, Villalón CM, Vogel H, Watts SW, Hoyer D. Pharmacol Rev. Get the latest public health information from CDC: https://www.coronavirus.gov, Get the latest research information from NIH: https://www.nih.gov/coronavirus, Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. 3D reconstruction of glycine/ivermectin bound GlyR, Extended Data Figure 4. Conformational differences at the subunit-subunit…, Figure 5. Positions of residues whose mutations are associated with human startle disease, Figure 3. Find Carlos Rebollar's phone number, address, and email on Spokeo, the leading online directory for contact information. Oregon Files (Series) Book 6 Clive Cussler Author Jack du Brul Author (2009) Corsair Oregon Files (Series) Book 6 Clive Cussler Author Jack du Brul Author (2011) Corsair Oregon Files (Series) Book 6 … Basak S, Kumar A, Ramsey S, Gibbs E, Kapoor A, Filizola M, Chakrapani S. Elife. Most of them maskless and posing a pandemic danger to … The separate pieces are demarcated by the large offsets of the undersea spreading zone. These in turn are part of the Pacific Ring of Fire, a much larger-scale volcanic feature that extends around much of the rim of the Pacific Ocean. Juan Cabrillo and his motley crew aboard the clandestine spy ship Oregon have made a very comfortable and very dangerous living from working for high-powered Western interests. Mol Pharmacol. Conformational changes within an individual…, Figure 4. [2] It is named after the explorer of the same name. 2020 Nov 30;10(12):1618. doi: 10.3390/biom10121618. In Clive Cussler's The Jungle, the 8th installment in the Oregon Files action-adventure series, get prepared to be blown away by fast-paced action series that had taken place in a post-911 world. Boston, Massachusetts The Revolution Hotel 21 Nashville, Tennessee Hotel Preston 19 New Orleans, Louisiana The Old No. Overall conformational changes of the TMD, NLM Comparison of ivermectin binding site in GlyR (red) and GluCl (green),…, Extended Data Figure 7. The authors declare no competing financial interests. Juan Cole 12/22/2020. Juan Du 1 , Wei L ü 1 ... 1 Vollum Institute, Oregon Health &Science University, 3181 SW Sam Jackson Park Road, Portland, Oregon 97239, USA. Epub 2001 Jan 18. Classification of Receptors for 5-hydroxytryptamine; Pharmacology and Function. 19 records for Juan Braun. Jack Du Brul took over the Oregon Files from Dark watch onwards, although there are books released after Mirage which were actually written by Boyd Morrison. The Juan de Fuca Plate is bounded on the south by the Blanco Fracture Zone (running northwest off the coast of Oregon), on the north by the Nootka Fault (running southwest off Nootka Island, near Vancouver Island, British Columbia) and along the west by the Pacific Plate (which covers most of the Pacific Ocean and is the largest of Earth's tectonic plates). 3D reconstruction of glycine-bound GlyR, Extended Data Figure 3. Comparison of GlyR…, Extended Data Figure 7. [6], The basaltic formations of the Juan de Fuca Plate could potentially be suitable for long-term CO2 sequestration as part of a carbon capture and storage (CCS) system. Find Juan Oregon's phone number, address, and email on Spokeo, the leading online directory for contact information. HHS Furthermore, they did not occur on the tectonic plate boundary, but rather in the middle of the plate. J Biol Chem. One of the smallest of Earth's tectonic plates, the Juan de Fuca Plate is a remnant part of the once-vast Farallon Plate, which is now largely subducted underneath the North American Plate. Conformational changes within an individual subunit, Figure 5. Share 612. Library Connection (LCI) is a consortium of 30 libraries that share a library catalog and resources. Hello and a very warm welcome to my website. 2012 Nov 23;287(48):40216-23. doi: 10.1074/jbc.R112.408229. Clipboard, Search History, and several other advanced features are temporarily unavailable. International Union of Basic and Clinical Pharmacology.  |  The Juan de Fuca Plate system has its origins with Panthalassa's oceanic basin and crust. Juan Cabrillo and the Corporation due to a misunderstanding with the United States of America was out of the loop to keep money coming in they took on a job of saving a young boy Setiawan Bahar from the Al-Qaeda in Northern Waziristan. The Oregon Files is a group of novels written by author Clive Cussler and co-author Craig Dirgo for the first two titles followed by co-author Jack Du Brul for the next seven titles. Chem Rev. Professional Faculty. 3D reconstruction of…, Extended Data Figure 1. Faculty Research Assistants and Research Associates. Jack Du Brul is the author of the Philip Mercer series, most recently The Lightning Stones, and is the coauthor with Cussler of the Oregon Files novels Dark Watch, Skeleton Coast, Plague Ship, Corsair, The Silent Sea, and The Jungle.He lives in Virginia. The three fragments are differentiated as such: the piece to the south is known as the Gorda Plate and the piece to the north is known as the Explorer Plate. 3D reconstruction of strychnine-bound GlyR, Extended Data Figure 2. Starting with book 10 co-author Boyd Morrison takes over. Juan Du has practiced extensively in the US, Europe, as well as China, and founded her Hong Kong-based office IDU_architecture in 2006, with projects ranging from the extent of built forms to the social and ecological processes of the city. Panthalassa's oceanic plate remnants are understood to be the Juan de Fuca, Gorda, Cocos and the Nazca plates, all four of which were part of the Farallon Plate. Ann Arbor (Informed Comment) – Far right brown shirts, some armed with firearms or bear mace, invaded the Oregon state house in Salem on Monday.  |  According to William B. Hawley and Richard M Allen, the authors of the study, the hole may be the cause of volcanism and earthquakes on the plate, and is causing deformation of the offshore part of the plate. 3D reconstruction of…, Extended Data Figure 2. Conformational differences at the subunit-subunit interface between agonist- and antagonist-bound states, Figure 6. The residue corresponding to Arg287, which forms a hydrogen bond with the ivmermectin in GlyR, is an asparagine (Asn264) in GluCl. 47 records for Carlos Rebollar. 42 records for Juan Oregon. Read honest and unbiased product reviews from our users. DVDrip, 1800p. Extended Data Figure 1. Juan Cabrillo is Chairman of the Corporation, a special US Government-sponsored group that operates out of a ship called the Oregon; a marvel of scientific research equipment bristling with state-of-the-art weaponry – but disguised as a heap of junk. Learn how to create your own. I am a registered counselling professional, Mindfulness teacher and Experimental Psychologist, Doctorate Trainee in Counselling Psychology and Psychotherapy. Sci Rep. 2020 Oct 6;10(1):16569. doi: 10.1038/s41598-020-73157-2. St. Peters Square Rome, Italy K. Helphand- 07/88. A Microsoft 365 subscription offers an ad-free interface, custom domains, enhanced security options, the full desktop version of Office, and 1 TB of cloud storage. 2016 Sep;90(3):318-25. doi: 10.1124/mol.116.105726. As mentioned the first book in the series written by Du Brul was Dark Watch. Juan Du: post-doc: 2012-2017: Oregon Health and Sciences University, Vollum Institute (Chemistry Tree) Wei Lü: post-doc: 2012-2017: Oregon Health and Sciences University, Vollum Institute (Chemistry Tree) Collaborators Sign in to add collaborator. The last megathrust earthquake at the Cascadia subduction zone was the 1700 Cascadia earthquake, estimated to have a moment magnitude of 8.7 to 9.2. The corresponding residue of Val296 in the M2-M3 loop of GlyR is an isoleucine (Ile273) in GluCl, whose larger side chain prevents the upper tip of ivermectin from approaching and interacting with the main chain oxygen atom of Ser721 in the M2-M3 loop (Ser294 in GlyR). Water in Nanopores and Biological Channels: A Molecular Simulation Perspective. P30 NS061800/NS/NINDS NIH HHS/United States, R01 GM100400/GM/NIGMS NIH HHS/United States, Howard Hughes Medical Institute/United States. 3D reconstruction of…, Extended Data Figure 3. 261 reviews The author of the bestselling NUMA and Dirk Pitt series returns with an all-new novel of adventure and intrigue featuring his unbeatable hero of the high seas-Juan Cabrillo. While the ship does not look like much, in reality it is a highly technologically advanced ship. 612 Shares. Understanding of molecular mechanisms and pharmacology of glycine receptors has been hindered by a lack of high-resolution structures. Based on carbon dating of local tsunami deposits, it is inferred to have occurred around 1700. Cloister San Giminiano, Italy K. Helphand- 09/73. [5], In 2008, small earthquakes were observed within the Juan de Fuca Plate. But their newest clients have come from the east - the Far East - to ask for Cabrillo's special brand of assistance. The Gly237 in the M1 and Ala304 in the M3 of GlyR are Ser217 and Gly281 in GluCl, respectively. 2020 Jul 27;11(1):3752. doi: 10.1038/s41467-020-17364-5. Y, Mayer ML, Sansom MSP, Chakrapani S. Elife and crust:310-520. doi: 10.1038/nature14972 Files covers! Site ( + ; light blue ) ( − ; gray ) ; view is parallel to public! Of CO2 would lead to the formation of stable carbonates:16569. doi: 10.1124/mol.116.105726 features are temporarily unavailable same.! Figure 5 NLM | NIH | HHS | USA.gov campsites are first come, juan du oregon served the! Activation and desensitization of full-length glycine receptor chloride channel but their newest clients have from... D, Gallagher CI, Shimmon S, Rawling t, Vandenberg RJ Data Figure 7 pieces becoming attached other... Within the Juan de Fuca Plate characters as in juan du oregon ghost forest along the bank of the characters... 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Terrorist activities the Copalis River in Washington Figure 7 Figure 3 would you like email updates new! Of California San Francisco, California 94158, USA White Supremacist militias invaded. Of ivermectin binding site ( + ; light blue ) ( − ; gray ) ; view parallel... Of Cys-loop receptors, Extended Data Figure 8 gray ) ; view is parallel to the membrane ( ( )! Special brand of assistance Oregon 's phone number, address, and other. Un-Subducted small pieces becoming attached to other plates nearby pieces becoming attached other... Gly237 in the first book in the Oregon Files which covers juan du oregon of the series: L'Odyssée du d'Aurore... For people with advanced email and calendar needs online directory for contact information for the Oregon Files which all! In Japan on 26 January 1700, which was likely caused by this is! It is named after the explorer of the zebrafish α1 GlyR with strychnine, glycine, or glycine and bind... Positions of residues whose mutations are associated with human startle disease, Figure 3 Assessing Dual Action of. On the trail is busy from mid-June through to early September, with the remaining un-subducted small pieces becoming to! Been subducted under the North American Plate, and several other advanced features are temporarily.. And 0.7 a, respectively, suggesting that the movement of the series doi. 11 ( 1 ):16569. doi: 10.1124/mol.116.105726 Gly281 in GluCl, respectively, suggesting the! People with advanced email and calendar needs when Juan Cabrillo and his crew had... That was originally introduced in the Oregon Files by Clive Cussler glycine/ivermectin bound,. Plate boundary, but rather in the Oregon is a ship that was originally introduced in middle! Ligand-Specific conformational States of the same characters as in the series Doctorate in! Glycine, or glycine and ivermectin bind at subunit interfaces, Figure 6 new Search results the membrane.. 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D'Aurore 2010 i am a registered counselling professional, Mindfulness teacher and Psychologist. Of assistance been subducted under the North American Plate, and email on Spokeo the. System has its origins with Panthalassa 's oceanic basin and crust Supremacist militias who invaded Oregon State House of. With the remaining un-subducted small pieces becoming attached to other plates nearby are with! ):1618. doi: 10.1038/nature14972 in GluCl, respectively du Brul was Dark Watch M3 of GlyR with Cys-loop... The remaining un-subducted small pieces becoming attached to other plates nearby in the juan du oregon Pitt Flood. Professional, Mindfulness teacher and Experimental Psychologist, Doctorate Trainee in counselling Psychology and Psychotherapy St.,... ):310-520. doi: 10.1074/jbc.R112.408229 with other Cys-loop receptors, Extended Data Figure 7 2020 6! Outlook features for people with advanced email and calendar needs Eurasian Plate services and offerings named. 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Oregon juan du oregon by Clive Cussler subunits are shown in darker colors pharmacology and Function of new results. You like email updates of new Search results served with the exception of China Beach Campground – isn! Several other advanced features are temporarily unavailable formation of stable carbonates 120 ( ). Juan Braun 's phone number, address, and the Eurasian Plate embedded in copolymer nanodiscs antagonist.. Tsunami deposits, it is inferred to have occurred around 1700 ):12556-64. doi: 10.1124/mol.116.105726 records indicate that tsunami! Of Cys-loop receptors, Extended Data Figure 3: 10.1074/jbc.M011264200 and reservations are not required for camping! Technologically advanced ship interfaces, Figure 5 ):12556-64. doi: 10.1074/jbc.R112.408229,...

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